Baby-aspirin risks overwhelm benefits in healthy elderly

Baby-aspirin risks overwhelm benefits in healthy elderly

Taking aspirin regularly does not significantly reduce the risk of heart attacks or stroke, a study has found.

These initial findings from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, partially supported by the National Institutes of Health, were published online on September 16, 2018 in three papers in The New England Journal of Medicine.

STEIN: Now, a daily baby aspirin is still totally smart for many people who have had a heart attack or stroke or are at risk for one. However, the higher death rate was due to more cancer deaths in the aspirin group, which could have been due to chance, the researchers said. Half the participants were asked to take 100mg of aspirin each day, while the rest took a placebo pill.

A large clinical trial involving participants in Australia and the US found a daily low-dose aspirin had no effect on prolonging life in healthy, elderly people.

"Clinical guidelines note the benefits of aspirin for preventing heart attacks and strokes in persons with vascular conditions such as coronary artery disease", said Richard J. Hodes, the director of the National Institute on Aging at the National Institutes of Health, which funded the study, in a news release.

The cancer finding surprised researchers because in other studies, aspirin protected against death from cancer. "What we've demonstrated is that there really is no significant benefit of being on a low dose daily aspirin if you're healthy and 70 and older, and that the risk of bleeding outweigh the benefits".

Anybody who has been taking low-dose aspirin for a long time is advised not to stop overnight as that may also cause problems.

But a new Australian-led study has found that's not the case.

Bond 25: True Detective's Cary Fukunaga replaces Danny Boyle as director
He could be the flawless collaborator to send off Craig's acclaimed take on James Bond in his fifth and final film. Fukunaga has previously flirted with major studio movies, having been signed on to direct Warner Bros.

Among the people assigned to take aspirin, 90.3 percent remained alive at the end of the treatment without persistent physical disability or dementia.

"So in terms of people previously well ... the evidence has come in and clearly shown that there is no benefit, and in fact, it can create secondary other issues which are obviously of concern".

Dr Nespolon said while there have been mixed opinions on whether giving healthy people aspirin is a good idea, this new study "clearly shows people over 70 shouldn't be taking aspirin as simply an aid to their health".

The aspirin not only failed to have any beneficial effect on lifespan but also carried a "higher risk of major hemorrhage" in the older adults, the authors stated. For cardiovascular disease, the rate was 10.7 events per 1000 person-years in the aspirin group and 11.3 events per 1000 person-years in the placebo group - also considered no difference.

"But we have not identified results that are strikingly different", McNeil said in an email.

Older adults should follow the advice from their own physicians about daily aspirin use, Hadley said.

"Interpretation of these results should take into account the lower-than-expected rate of cardiovascular disease among the trial participants. most likely reflecting the relatively good health of the participant population at recruitment and the declining rate of cardiovascular disease in the two countries over time and across all age groups", the investigators suggested.

Prof McNeil cautioned the findings did not apply to those with existing conditions where aspirin is recommended as a preventative measure against further heart attacks, strokes or angina.

Related Articles

  • Trump Visits Hurricane-Ravaged North Carolina

    Trump Visits Hurricane-Ravaged North Carolina

    Of the 36 people confirmed dead in the storm by local authorities, 27 died in North Carolina , eight in SC and one in Virginia. Trump listed off the successes: 3,000 people rescued, 1.6 million meals provided, power restored to 1.2 million homes.
    Champions League: Liverpool makes headway in PSG home-opener

    Champions League: Liverpool makes headway in PSG home-opener

    According to Uefa's official statistics the PSG goalkeeper Alphonse Areola suffered as many fouls (two) as Neymar , ... "It was a great performance from Daniel", said Liverpool manager Juergen Klopp after their opening Group C game.
    Elizabeth Smart kidnapper Wanda Barzee released from prison today

    Elizabeth Smart kidnapper Wanda Barzee released from prison today

    The 18-year-old cousin looks a lot like Smart, who had been specifically selected by Mitchell and Barzee, police said. Smart criticized officials for letting Barzee out of prison, saying she believes that her captor is still a "threat".
  • Arteta tips City to conquer Champions League

    Arteta tips City to conquer Champions League

    We will try to reduce the impact and give the players what they need and hopefully it will work well. "It is disappointing. First-half goals from Maxwel Cornet and Nabil Fekir punished mistakes from City duo Fabian Delph and Fernandinho .
    Trump Says He Wants To Hear From Kavanaugh's Accuser

    Trump Says He Wants To Hear From Kavanaugh's Accuser

    Back in 1991, however, the FBI did investigate sexual harassment claims against then-Supreme Court nominee Clarence Thomas. "Very hard for me to imagine that anything happened".
    This Band To Perform During Super Bowl LIII Halftime Show

    This Band To Perform During Super Bowl LIII Halftime Show

    The NFL has released a statement on the rumor that Adam Levine 's Maroon 5 will be the 2019 Super Bowl halftime show performer. The point here is that Super Bowl LIII will be played in Atlanta, a culturally rich city known as a mecca for hip hop and R&B.
  • Dont'a Hightower: Josh Gordon is 'still a monster'

    Dont'a Hightower: Josh Gordon is 'still a monster'

    It's very possible we see him step on the field this week against the Detroit Lions . Brady had his first practice with Gordon on Wednesday.
    Sky and Netflix announce plans to create 'ultimate' TV package

    Sky and Netflix announce plans to create 'ultimate' TV package

    Sky and Netflix shows sits side-by-side on Sky Q's content rails, some of which are tailored around the viewer's usage history. Normally, that costs £7.99 a month - but then they're also getting access to Sky Box Sets which is normally a fiver a month.
    He is small, but he is wow - Guardiola champions Bernardo Silva

    He is small, but he is wow - Guardiola champions Bernardo Silva

    Last season, second-tier Preston had 105-year-old Bernard Jones lead them out for a second-tier fixture. Last year, the club became the only English club to get more than a 100 points in a season.
  • US Is Ready To Negotiate With North Korea

    US Is Ready To Negotiate With North Korea "Immediately": Mike Pompeo

    The two sides agreed to break the impasse during Kim Jong Un's historic meeting with Trump in Singapore in June. Unlike Trump's initial tweets praising the summit, the news brought a quick and negative response from Sen.
    Liverpool's James Milner trolls Neymar with hilarious Instagram post

    Liverpool's James Milner trolls Neymar with hilarious Instagram post

    We know it won't be the easiest game for us with a game every three days but we have to take it seriously and try to do our best".

    Jimmy Butler has Knicks, Nets on three-team trade list

    It may seem a bit surprising at first, because, well, they aren't very good at basketball as now constructed. A potential package that does work under those guidelines would be Hardaway, Thomas and a first-round pick.