First baby born after uterus transplant from dead donor

First baby born after uterus transplant from dead donor

This isn't the first baby born to a woman with a uterine transplant-several have been born in Sweden, the USA, and Brazil to women who received uterine transplants from live donors.

With live donors in short supply, doctors say the new technique might help to increase availability and give more women the option of pregnancy. The baby was delivered by caesarean section in December 2017. Uterus transplantation, even from living donors, is still a very new procedure. They cite women with inoperable fibroids, or abnormal uterine growths, those who have experienced embryo implantation failure and those who have received pelvic radiation as categories of women who may be able to benefit from uterus transplantation in the future.

The uterus was taken from a 45-year-old donor who had died from a brain haemorrhage.

The uterus from the deceased donor was implanted during a 10-hour operation.

"The first uterus transplants from live donors were a medical milestone, creating the possibility of childbirth for many infertile women with access to suitable donors and the needed medical facilities".

The woman, 32, was initially scared of the procedure, said Dr. Dani Ejzenberg, who is the transplant team's lead doctor at the University of Sao Paulo School of Medicine, as AP reported. Until now, the only successful uterus transplants have involved living donors who are typically family members of the recipients.

Moreover, the doctors said that while a transplanted kidney or liver stays for life, it is not the case with the uterus. Doctors then removed the uterus so the mother would not have to continue anti-rejection medications.

"When a transplant is dome from a live donor, there is a greater responsibility towards both the donor and recipient, but in a dead body the doctors can be a bit relaxed", Ms Sharma said.

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The world's first baby has been born via a uterus transplanted from a dead donor.

IVF Australia medical director Associate Professor Peter Illingworth said using deceased donors avoided the need for women to undergo major surgery and the risk of complications in order to donate their uterus to their loved one.

"The pregnancy in the first attempt, with the transfer of only one embryo, surprised us, but we were confident of achieving gestation due to the quality of the staff of our human reproduction center that has worked for 15 years with good results", Ejzenberg says.

Six weeks after the uterine transplant, which was performed in 2016, the Brazilian woman started having periods again. This affects approximately 3 to 5 per cent of women, Dr. Tullius said, including those born without a uterus or those who have had hysterectomies for cancer-related reasons. The recipient tolerated the transplant relatively well thanks to immunosuppression drugs, other treatments and constant monitoring.

"Successful pregnancy, without evidence of any compromise in spite of the uterus (womb) being without oxygen for eight hours before transplant, was unique".

Uterine transplants aren't about to become standard just yet.

In this trial, the mother was given standard doses of immune suppression medications for nearly six months, with positive results, before implantation of the embryo was completed.

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